Page 299 - ATP-P 11th Ed

Description: Macrolide antibiotic
Indications:
• Acute bacterial sinusitis
• Mild community-acquired pneumonia
• Chancroid (genital ulcer disease)
• Pharyngitis/tonsillitis as alternative drug choice to first line therapy
• Uncomplicated skin infections
• Urethritis
Adult dose:
• For most bacterial infections: 500mg as single dose on day 1, then 250mg daily on days
2 through 5.
• For gonorrhea: 2g PO as a single dose.
Pediatric dose: (6 months of age or older)
• Z-Pak is not indicated for children. The oral suspension is the only dose approved for
®
use in children, and is dosed on a mg/kg basis.
• 10mg/kg up to 500mg the first day; then 5mg/kg up to 250mg for the next 4 days
Contraindications: SECTION 3
• Known allergy to azithromycin
• Pregnancy
• Z-Pak in children
®
• Patients receiving:
®
° Astemizole (Hismanal ) – antihistamine taken off of the US market
®
° Cisapride (Propulsid ) – GI medication taken off of the US market
Pregnancy Category B
Side-effects:
• Generally mild and reversible upon discontinuation of therapy
• Nausea, vomiting, diarrhea, abdominal pain
Adverse reactions:
• Rare:
° Angioedema (swelling of the larynx)
° Cholestatic jaundice
• Hypersensitivity
Other notes:
• Can be taken with or without food.
• Continue regimen for duration of prescription.
TMEP use:
• Bronchitis/Pneumonia Protocol
• Ear Infection Protocol
• Gastroenteritis Protocol
• Urinary Tract Infection Protocol

ATP-P Handbook 11th Edition 289