Page 296 - ATP-P 11th Ed

Other notes:
• Take daily dose at the same time every day with food or milk
• If vomiting occurs within 1 hour of dosing, repeat the dose
• Treatment has not been evaluated for treatment of cerebral malaria or other severe mani-
festations of complicated malaria
• Absorption may be reduced in patients with diarrhea or vomiting. May need to add
antiemetic to prevent vomiting.
• Include protective clothing, insect repellants, bed nets as important components of
malaria prophylaxis
• If a dose is skipped, take it as soon as possible, and then return to normal schedule. Do
not double the next dose.
TMEP use: Malaria Protocol

Dosage of Atovaquone/Proguanil in
Prevention of Malaria in Pediatric Patients
SECTION 3 Weight (kg) Total Daily Dose Dosage Regimen
62.5mg/25mg
11 to 20
1 pediatric tablet daily
21 to 30 125mg/50mg 2 pediatric tablets as a single daily dose
31 to 40 187.5mg/75mg 3 pediatric tablets as a single daily dose
>40 250mg/100mg 1 tablet (adult strength) as a single daily dose
Dosage of Atovaquone/Proguanil in
Treatment of Malaria in Pediatric Patients
Weight (kg) Total Daily Dose Dosage Regimen
5 to 8 125mg/50mg 2 tablets (pediatric strength) daily for
3 consecutive days
9 to 10 187.5mg/75mg 3 tablets (pediatric strength) daily for
3 consecutive days
11 to 20 250mg/100mg 1 tablet (adult strength) daily for
3 consecutive days
21 to 30 500mg/200mg 2 tablets (adult strength) as single daily dose
for 3 consecutive days
31 to 40 750mg/300mg 3 tablets (adult strength) as single daily dose
for 3 consecutive days
>40 1g/400mg 4 tablets (adult strength) as single daily dose
for 3 consecutive days

286 SECTION 3 RECOMMENDED DRUG LIST (RDL)