Page 110 - 2026 SMOG

CEFTRIAXONE (ROCEPHIN)
Class/Mechanism of Action
• Antibiotic, Cephalosporin
Inhibits bacterial cell wall synthesis by binding to one or more of the penicillin-binding
proteins (PBPs), which in turn inhibits the final transpeptidation step of peptidoglycan synthesis
in bacterial cell walls, thus inhibiting cell wall biosynthesis.
Indications
• Labeled Indications
˚ Infections
Meningitis
˚
• Off-Label Indications
˚ Animal or human bite wound treatment
Contraindications
• Hypersensitivity to Ceftriaxone or any component of the formula and/or other cephalosporins
Adverse Reactions/Precautions
• Skin tightness
• Diarrhea
• Do NOT use in hyperbilirubinemic neonates
Dose/Administration
PEDIATRIC
ADULT
(Always reference Broselow Tape)
Sepsis Sepsis
• IV/IO • IV/IM
˚ 2g over 10min q24hr ˚ Infants, children, and adolescents:
50–75mg/kg/dose q24hr
OR
25–37.5mg/kg/dose q12hr
■ Max daily dose: 2g/day
Note: Higher doses are recommended in
certain infections (e.g., endocarditis,
meningitis). Refer to the doctor’s orders for
the specified treatment plan.

102 • MEDICATIONS