Page 109 - 2026 SMOG

CEFAZOLIN (ANCEF)
Class/Mechanism of Action
• Antibiotic (Cephalosporin 1st Gen)
Bactericidal: Inhibits bacterial cell wall synthesis by binding to one or more penicillin-binding
proteins, which inhibits cell wall biosynthesis, causing bacteria to lyse eventually.
Indications
• Labeled Indications
˚ Used for infection control prophylaxis for traumatic open injuries and surgical prophylaxis
Contraindications
• Hypersensitivity to cefazolin, other cephalosporin antibiotics, other betalactams, or any
component of the formulation
• Some crossreactions occur in those with penicillin allergies. Use with caution
Adverse Reactions/Precautions
• Superinfection: prolonged use may result in fungal or bacterial superinfection (including
C.Difficile)
• Increased INR (bleeding risk), especially in nutritionally deficient, hepatic/renal disease, and
prolonged treatment
• Pregnancy: Safe
• Lactation: Considered safe; trace amounts found in breast milk
Dose/Administration
PEDIATRIC
ADULT
(Always reference Broselow Tape)
Infection Control Infection Control
• IV • IV
˚ 2g in 250mL NS over 5min q8hr for ˚ 20–30mg/kg q6–8hr (max DAILY dose:
100mg/kg/day)
24hr. This is adequate for most dirty
wounds of the head and neck, torso, and
extremities
Note: See the antibiotic chart for dosing in
accordance with the injury

2026 Standard Medical Operating Guidelines (SMOG) • 101