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TABLE 1  Experts’ Demographic Data, Specialties, and Experiences   fluids, and pressor amines. Since REBOA has potentially se-
              with REBOA                                         rious complications, 16–18  it is important to identify the cases
                                            Years of   No. of    that, after receiving medical care, are deemed too serious and
                                            practice as   REBOA   non-responsive  to  conventional  treatments. These  would  be
              Country         Specialty      senior   inflated   the patients unlikely to get to the hospital alive and for whom
              Italy      General surgery      21        30       REBOA would be the only therapeutic tool allowing survival.
              USA        Trauma surgery       10        15       The  proposed protocol  does  not encourage  systematic  use
              Israel     Trauma surgery       20        15       of REBOA in patients who could be saved by conventional
              Turkey     Emergency medicine    5        8        therapeutics that are less invasive and have fewer potential
              USA        Trauma surgery        1        15       complications.
              Switzerland  Vascular surgery   20        25       Responses and Credibility of the Experts
              Sweden     Vascular surgery      5        4        It is assumed that the experts predominantly answered based
              Israel     General surgery      27        21       on their personal opinions and experiences.  The majority
              Israel     Vascular surgery     21        12       of our experts have sound experience in REBOA use, with
              Sweden     Intensive care        1        4          REBOA being performed a median of 12 times per year, giving
              Sweden     Vascular surgery      8        100      legitimacy to our study.
              Russia     trauma surgeon       10        25
              Sweden     Vascular surgery      4        8        Suggested Protocol
              Israel     General surgery      21        15       Based on the answers to the questions posed in our study,
              England    Emergency medicine    9        5        compiled along with the existing recommendations regarding
              USA        Pediatric surgery     7        2        REBOA, we propose a protocol for REBOA use in a civilian
                                                                 prehospital setting. The specificity of our system in France,
              USA        Trauma surgery        6        20       where a surgeon is not available in the prehospital setting,
              France     Intensive care        2        3        made it unnecessary to compare REBOA with resuscitative
              Sweden     Vascular surgery      1        2        thoracotomy, a procedure which would be relevant in a hospi-
              REBOA = resuscitative endovascular balloon occlusion of the aorta.  tal setting. 6,19  Figure 1 synthesizes our protocol as a decisional
                                                                 algorithm.
              have the legal possibility to use all medical therapies. Paramed-
              ics can only use medications for which a protocol has been   Indications and Contraindications
              authorized. Indeed, in a medicalized prehospital system, be-  REBOA is used for patients in hemorrhagic shock of an ab-
              fore reaching the need for REBOA, the physician has other   dominal, pelvic, or junctional origin or in the postpartum con-
              therapeutic means to resuscitate the patient and stabilize their   text. We consider supra-aortic trunk trauma to be an absolute
              hemodynamics—including blood, blood plasma, intravenous   contraindication  to  REBOA.  Additionally,  REBOA  use  can

              TABLE 2  Ten Questions Submitted to the Experts and Their Answers
                                                                                    Answer, %
                                                                                                  Round   No. of
              Question                                                            Yes      No    number   answers
              In your opinion, is there an indication of REBOA for a patient in cardiac arrest due to   76  24  1  17
              hemorrhagic shock, whose lesions can be reached by REBOA?
              In your opinion, is there an indication of REBOA for a patient in uncontrolled hemorrhagic   94  6  1  17
              shock after a post-partum hemorrhage?
              In your opinion, in a hemorrhagic patient, vascularly well-filled and whose hemodynamics   94  6  2  18
              remain unstable with 3 mg/h of norepinephrine, should we inflate a REBOA to prevent the
              patient’s death and get them to the operating room alive?
              Would you agree that it might be useful to place a desilet upstream of the common femoral   94  6  2  18
              artery (CFA) (without setting up the REBOA), in a hemorrhagic shock state patient, cared
              for in the prehospital setting, in the situation where their medical condition would be
              declining and it would be necessary to set up and inflate a REBOA during transport?
              Would you say that REBOA is useful for a patient in cardiorespiratory arrest (CRA) due to   26  74  2  19
              a hemorrhagic shock with lesions reachable by the REBOA, and with a no-flow time of over
              5 minutes?
              In the case of REBOA placement (zone I) in the prehospital setting, would you agree that   74  26  2  19
              the maximum occlusion duration is approximately 30 minutes, with a partial or intermittent
              occlusion when possible?
              Would you agree that the best approach to the use of REBOA in the prehospital setting   89  11  2  19
              would be a 10- or 20-minute complete occlusion, followed by a partial and gradual
              deflation, depending on the patient’s systolic blood pressure?
              In your opinion, to place a REBOA in the prehospital setting, and to respect minimal aseptic   84  16  2  19
              technique, would it be sufficient to wear sterile gloves and eventually use a sterile field?
              Do you agree that out-of-hospital REBOA should be used after notifying the trauma center   85  15  3  20
              doctor, when possible?
              Do you agree that if REBOA is indicated, the physician on the field must be limited to two   90  10  3  20
              attempts or 5 minutes to place the introducer?
              REBOA = resuscitative endovascular balloon occlusion of the aorta.

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