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data may stimulate further investigation into the natural his- 3. Principi N, Piralla A, Zampiero A, et al. Bocavirus infection in
tory and the transmission patterns of this emerging pathogen. otherwise healthy children with respiratory disease. PLoS One.
While HBoV may not be a highly virulent or a highly trans- 2015;10(8):e0135640. Published online 2015 August 12.
missible pathogen at present, previous studies have indicated 4. Jartti T, Hedman K, Jartti L, Ruuskanen O, Allander T, Söder-
that it has the potential to become a serious cause for con- lund-Venermo M. Human bocavirus: the first 5 years. Rev Med
Virol. 2012;22(1):46–64.
cern. One of these studies has reported that different strains of 5. Kesebir D, Vazquez M, Weibel C, et al. Human bocavirus infec-
HBoV can swap and recombine genetic material. This “gene tion in young children in the United States: molecular epidemi-
22
swapping” may lead to increasing awareness that new or more ological profile and clinical characteristics of a newly emerging
virulent strains can emerge. There is also evidence that this respiratory virus. J Infect Dis. 2006;194(9):1276–1282.
23
virus can interact with other viral pathogens in the host, pos- 6. Christensen A, Kesti O, Elenius V, et al. Human bocaviruses and
sibly leading to increased pathogenicity. 22 paediatric infections. Lancet Child Adolesc Health. 2019;3(6):
418–426.
7. Schildgen O, Müller A, Allander T, et al. Human bocavirus:
Georgia was the largest non-NATO contributor to the Reso- passenger or pathogen in acute respiratory tract infections? Clin
lute Support mission in Afghanistan. In addition, Georgia has Micro biol Rev. 2008;21(2):291–304.
participated in numerous NATO and European Union peace- 8. Wang K, Wang W, Yan H, et al. Correlation between bocavirus
keeping operations, and it deployed several combat infantry infection and humoral response, and co-infection with other
brigades to assist US forces in Iraq. It is anticipated that US respiratory viruses in children with acute respiratory infection.
J Clin Virol. 2010;47(2):148–155.
military personnel will continue to work side by side with 9. Chow BD, Esper FP. The human bocaviruses: a review and discus-
their Georgian counterparts in Georgia and throughout the sion of their role in infection. Clin Lab Med. 2009;29(4):695–713.
world. Understanding the impact of HBoV and other emerg- 10. Lee HN, Koo HJ, Kim SH, Choi SH, Sung H, Do KH. Human
ing pathogens on the Georgian military will allow the medical bocavirus infection in adults: clinical features and radiological
personnel of the US Special Operations community to better findings. Kor J Radiol. 2019;20(7):1226–1235.
assist in the diagnosis and treatment of both Georgian and US 11. Ishiguro T, Hirota S, Kobayashi Y, et al. Fatal primary human
military personnel. It is therefore recommended that military bocavirus pneumonia in an immunocompetent adult. Intern Med.
2020;59(3):421–424.
medical personnel operating in Georgia and throughout the 12. Hang VTT, Ny NTH, Phuc TM, et al. Evaluation of the Luminex
Caucasus region become familiar with HBoV and that HBoV xTAG Respiratory Viral Panel FAST v2 assay for detection of
be considered in the differential diagnosis of acute respiratory multiple respiratory viral pathogens in nasal and throat swabs in
infection. This may be especially important in cases where the Vietnam. Version 2. Wellcome Open Res. 2017;2:80. Published
symptoms are more severe than expected during the winter online 2018 Apr 30.
and early spring months and when there is a possibility for 13. Xu M, Arku B, Jartti T, et al. Comparative diagnosis of human bo-
cavirus 1 respiratory infection with messenger RNA reverse-tran-
coinfection or confounding with SARS-CoV-2. It is also rec- scription polymerase chain reaction (PCR), DNA quantitative
ommended that surveillance efforts be directed toward deter- PCR, and serology. J Infect Dis. 2017;215(10):1551–1557.
mining the actual burden of HBoV in the Georgian population 14. Calvo C, García-García ML, Pozo F, Carballo D, Martínez-Mon-
and that research be undertaken to determine the mechanisms teserín E, Casas I. Infections and coinfections by respiratory
of HBoV pathogenesis, so that informed decisions can be human bocavirus during eight seasons in hospitalized children.
J Med Virol. 2016;88(12):2052–2058.
made regarding the development and selection of diagnostic 15. Tymentsev A, Tikunov A, Zhirakovskaia E, et al. Human boca-
and treatment protocols capable of mitigating the threat of virus in hospitalized children with acute gastroenteritis in Russia
this agent to military personnel in Georgia. from 2010 to 2012. Infect Genet Evol. 2016;37:143–149.
16. Abdel-Moneim AS, Mahfouz ME, Zytouni DM. Detection of hu-
Disclaimers man bocavirus in Saudi healthy blood donors. PLoS One. 2018;
The views expressed in this document are those of the authors 13(2):e0193594. Published online 2018 February 28.
and do not reflect the official policy or position of the United 17. Vo MT, Bruhn R, Kaidarova Z, Custer BS, Murphy EL, Bloch
States Army, the United States Military Academy or the United EM. A retrospective analysis of false-positive infectious screening
results in blood donors. Transfusion. 2016;56(2):457–465.
States Department of Defense. 18. Clemmons NS, McCormic ZD, Gaydos JC, Hawksworth AW,
Jordan NN. Acute respiratory disease in US Army trainees 3 years
Disclosure after reintroduction of adenovirus vaccine 1. Emerg Infect Dis.
The authors have no affiliations with or involvement in any 2017;23(1):95–98.
organization or entity with any financial interest in the mate- 19. Georgia Adult Literacy Rate. https://knoema.com/atlas/Georgia
rial discussed in this manuscript. /topics/Education/Literacy/Adult-literacy-rate. Retrieved January
16, 2020.
20. Salez N, Vabret A, Leruez-Ville M, et al. Evaluation of four com-
Funding mercial multiplex molecular tests for the diagnosis of acute re-
This work was financially supported by the Armed Forces spiratory infections. PLoS One. 2015;10(6):e0130378. Published
Health Surveillance Branch, Global Emerging Infections Sur- online 2015 June 24.
veillance and Response System (AFHSB-GEIS), Silver Spring, 21. Kissler SM, Tedijanto C, Goldstein E, Grad YH, Lipsitch M. Pro-
Maryland, USA (ProMIS ID: 20160280193, Funding Year: jecting the transmission dynamics of SARS-CoV-2 through the
postpandemic period. Science. 2020;368(6493):860–868.
2016). 22. Brockmann M, Windisch W, Hedman K, et al. HBoV-1 in pleura
of an adult patient in Cologne, Germany. JMM Case Rep. 2014;1
References (3):e003657.
1. Guido M, Tumolo MR, Verri T, et al. Human bocavirus: current 23. Zhao M, Zhu R, Qian Y, et al. Prevalence analysis of different
knowledge and future challenges. World J Gastroenterol. 2016;22 human bocavirus genotypes in pediatric patients revealed intra-
(39):8684–8697. genotype recombination. Infect Genet Evol. 2014;27:382–388.
2. Verbeke V, Reynders M, Floré K, et al. Human bocavirus infec-
tion in Belgian children with respiratory tract disease. Arch Virol.
2019;164(12):2919–2930.
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