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TABLE 1  Core Temperature Thresholds for Primary (Accidental)   It was not until recently that the HPMK’s effectiveness was
              Versus Secondary (Trauma-Induced) Hypothermia Classification 43  evaluated using human volunteers in a cold (−22°C [−7.6°F])
                                  Accidental    Trauma-Induced   chamber study.  Five active, heated hypothermia enclosure
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                 Classification  Hypothermia     Hypothermia     systems (also known as hypothermia wraps) were compared.
                                  32°C–35°C       34°C–36°C      The results indicated that the HPMK (noninsulated), as com-
              Mild hypothermia  (89.6°F–95.0°F)  (93.2°F–96.8°F)  pared with three other commercial, insulated, active heated
              Moderate            28°C–32°C       32°C–34°C      hypothermia enclosure systems and one user-assembled, insu-
              hypothermia       (82.4°F–89.6°F)  (89.6°F–93.2°F)  lated, active heated hypothermia enclosure system, was ranked
              Severe hypothermia  <28°C (<82.4°F)  <32°C (<89.6°F)  the lowest in both subjective ratings and objective physiologi-
                                                                 cal heat transfer and balance indices. 22
              components. 12,29,30,50  A lack of warm IV fluids is an iatrogenic
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              contributor to the lethal triad, particularly when administer-  These findings by Dutta et al.  and feedback from the field
              ing large fluid volumes.  In a prospective multicenter study   regarding HPMK limitations resulted in the CoTCCC under-
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              of trauma patients who required massive transfusion, it was   taking a comprehensive literature review to update the current
              reported that hypothermia on arrival was an independent   recommendations for treating casualties with hypothermia.
              predicator of mortality.  Furthermore, the authors reported   The following are specific questions addressed by the CoTCCC
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              that every decrease of 1.0°C (1.8°F) in core temperature below   in 2019 regarding the battlefield (prehospital) management of
              36°C (96.8°F)  resulted in  a 10% increase  in red blood cell   all-cause hypothermia:
              (RBC) consumption in the first 24 hours of admission. These
              authors and others  concluded that hypothermia (<36°C) is   (1)  Is adding an external heat source to a hypothermia wrap
                             15
              associated with increase in blood-product consumption and   effective?
              mortality. These data emphasized the need for effective hy-  (2)  Is an improvised, user-assembled, heated hypothermia
              pothermia prevention at the point of injury (POI) and contin-  wrap effective?
              ued patient warming during massive transfusion with warmed   (3)  What is the most effective method to apply an active heat
              (38°C–42°C [100.4°F–107.6°F]) whole blood.            source to the casualty in a hypothermia wrap to prevent
                                                                    and/or treat hypothermia?
              Commercial, battery-powered, in-line IV warming devices, as   (4)  What are the indications, contraindications, safety is-
              well as improvised IV warming methods, inconsistently warm   sues, and complications associated with applying an ex-
              blood to the target temperature from cold ambient tempera-  ternal heat source inside a hypothermia wrap during field
              tures. 53–56  Also, battery-powered, in-line IV warming devices   management?
              do not have equal performance characteristics or easy set-up   (5)  What are the required characteristics of a portable IV
              methods for IV delivery of blood. 55–59               warming device for infusion of fluids and blood products?
                                                                 (6)  What are the relevant safety concerns for a portable, bat-
              One basic requirement for managing cold-stressed (>35°C   tery-operated, IV warming device? 11
              [95°F]) or hypothermic (<35°C) combat casualties is the
              ability to enclose them in a hypothermia wrap consisting of   Overview of Prehospital
              an enclosure, insulation, vapor barrier, and an external heat   Hypothermia-Wrap Systems
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              source.  Wool blankets have been the standard for treating
              hypothermic combat casualties dating back to World War   The evidence for both passive and active external rewarming
              I. 4,11,20  This long-standing hypothermia management approach   treatment options has been discussed for decades 23,24  and was
              did not advance significantly after many wars and conflicts un-  recently reviewed for treating hypothermic patients in the pre-
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              til the implementation of the use of the HPMK.  The HPMK   hospital environment.  The authors concluded that prehospital
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              was one component of the Joint Theater Trauma System’s   warming inside a hypothermia wrap is safe and advantageous,
              (JTTS) theater-wide strategy to address hypothermia in battle-  especially for a nonshivering hypothermic patient with or with-
              field casualties and was recommended in the clinical practice   out injuries. This review revealed that hypothermia enclosure
              guidelines.  This JTTS strategy demonstrated the need for a   systems that include more insulation and active heat sources
                      21
              systematic approach to performance improvement, which in-  perform better for patient treatment.  Table 2 lists relevant pre-
              cludes research and development, clinical practice guidelines,   hospital passive 62–66  insulation and active 22,56,57,61,67–69  rewarm-
              education, training, and monitoring outcomes for care at the   ing enclosure systems, graded by the level of evidence.  The
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              POI during medical evacuation, and at each role of care in   prevention of heat loss should begin aggressively soon after
              the operational environment to decrease TIH mortality. 8,11,60    injury, as should active external heating, if possible.
              However, a survey of battlefield medical care from 2009 and
              2011 revealed that wool blankets, not the HPMK, were still   Rewarming hypothermic patients can be passive, using the
              being used in some cases for managing and preventing hypo-  casualty’s own heat production from shivering, or active, pro-
              thermia. 19,20  The decision to add the HPMK to the CoTCCC   viding external heat to the casualty. Active warming is rec-
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              Guidelines was supported by the findings of Allen et al.,  who   ommended, especially for trauma patients; it will warm the
              evaluated three passive and five active hypothermia-warming   skin; decrease shivering (without negative effects on core re-
              systems. Even though there were good results with the HPMK,   warming) and, therefore, decrease the work of the heart; and
              this study was not conducted with human volunteers; the re-  increase the casualty’s comfort level and general psychological
              searchers measured heat flux changes in warmed fluid blad-  outlook. Although active warming may not be necessary, it
              ders as a method to simulate a human torso. These authors   will do no harm in hypothermic patients and will be helpful. 57
              noted this was a study limitation and made a recommendation
              that future studies on hypothermia enclosure systems be con-  An improvised rewarming method is used to create a hypo-
              ducted with human volunteers.                      thermia wrap (also known as a “burrito wrap”). This consists

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