Page 136 - JSOM Fall 2020

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22. Djabir Y, Letson HL, Dobson GP. Adenosine, lidocaine and Mg 36. Granfeldt A, Letson HL, Hyldebrandt JA, et al. Small-volume
(ALM) increases survival and corrects coagulopathy after 8 min 7.5% NaCl adenosine, lidocaine and Mg has multiple benefits
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asphyxial cardiac arrest in the rat. Shock. 2013;40(3):222–232. during hypotensive and blood resuscitation in the pig following
23. Letson HL, Dobson GP. Unexpected 100% survival following severe blood loss: rat to pig translation. Crit Care Med. 2014;42
60% blood loss using small-volume 7.5% NaCl with adenocaine (5):e329–e344.
and Mg in the rat model of extreme hemorrhagic shock. Shock. 37. Granfeldt A, Letson HL, Dobson GP, et al. Adenosine, lidocaine
2+
2011;36(Dec 6):586–594. and Mg improves cardiac and pulmonary function, induces re-
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24. Griffin MJ, Letson HL, Dobson GP. Adenosine, lidocaine and versible hypotension and exerts anti-inflammatory effects in an
Mg (ALM) induces a reversible hypotensive state, reduces lung endotoxemic porcine model. Crit Care. 2015;18( 6):682.
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edema and prevents coagulopathy in the rat model of polymicro- 38. Letson HL, Granfeldt A, Jensen TH, et al. ALM supports a high
bial sepsis. J Trauma Acute Care Surg. 2014;77(3):471–478. flow, hypotensive, vasodilatory state with improved O delivery
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25. Griffin MJ, Letson HL, Dobson GP. Small-volume adenosine, li- and cerebral protection in a pig model of non-compressible hem-
docaine and Mg (ALM) 4 hour infusion leads to 88% survival orrhage. J Surg Res. 2020;253(Sept):127–138.
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after 6 days of experimental sepsis in the rat without antibiotics. 39. How RA, Glaser JJ, Schaub LJ, et al. Prehospital adenosine, lido-
Clin Vaccine Immunol. 2016;23(11):863–872. caine, and magnesium has inferior survival compared with Tac-
26. Davenport L, Letson HL, Dobson GP. Immune-inflammatory ac- tical Combat Casualty Care Resuscitation in a porcine model of
tivation after a single laparotomy in a rat model: effect of adenos- prolonged hemorrhagic shock. J Trauma Acute Care Surg. 2019;
ine, lidocaine and Mg infusion to dampen the stress response. 87(1):68–75.
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Innate Immun. 2017;23(5):482–494. 40. Letson H, Dobson GP. Buprenorphine analgesia reduces survival
27. Letson HL, Pecheniuk NM, Mhango LP, Dobson GP. Reversal with ALM resuscitation in a rat model of uncontrolled hemor-
of acute coagulopathy during hypotensive resuscitation using rhage: concerns for trauma-related research. Shock. 2020.
small-volume 7.5% NaCl with adenocaine and Mg in the rat 41. Letson HL, Dobson GP. Buprenorphine analgesia: new adverse
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model of severe hemorrhagic shock. Crit Care Med. 2012;40: effects emerge. Shock. 2020;54(2):272.
2417–2422. 42. Heegaard PMH, Miller I, Sorenson NS, et al. Pig a1-acid glyco-
28. Dobson GP, Morris JL, Davenport LM, et al. Traumatic-induced protein: characterization and first description in any species as a
coagulopathy as a systems failure: a new window into hemosta- negative acute phase protein. PLoS One. 2013;8(7):e68110.
sis. Semin Thromb Hemost. 2020;46(2):199–214. 43. Smith SA, Waters NJ. Pharmacokinetic and pharmacodynamic
29. Torres Filho IP, Torres LN, Salgado C, Dubick MA. Novel ad- considerations for drugs binding to alpha-1-acid glycoprotein.
junct drugs reverse endothelial glycocalyx damage after hemor- Pharm Res. 2019;36:30.
rhagic shock in rats. Shock. 2017;48(5):583–589. 44. Huang Z, Ung T. Effect of alpha-1-acid glycoprotein binding on
30. Letson HL, Dobson GP. 3.0% NaCl adenosine, lidocaine, Mg pharmacokinetics and pharmacodynamics. Curr Drug Metab.
2+
(ALM) bolus and 4 hours ‘drip’ infusion reduces non- compressible 2013;14(2):226–238.
hemorrhage by 60% in a rat model. J Trauma Acute Care Surg. 45. Weinberg L, Peake B, Tan C, et al. Pharmacokinetics and phar-
2017;82(6):1063–1072. macodynamics of lignocaine: a review. World J Anesthesiol.
31. Letson HL, Dobson GP. Adenosine, lidocaine and Mg (ALM) 2015;4(2):17–29.
2+
fluid therapy attenuates systemic inflammation, platelet dysfunc- 46. Downing NS, Shah ND, Aminawung JA, et al. Postmarket safety
tion and coagulopathy after non- compressible truncal hemor- events among novel therapeutics approved by the US Food and
rhage. PLoS ONE. 2017;12(11):e0188144. Drug Administration between 2001 and 2010. JAMA. 2017;317
2+
32. Letson HL, Dobson GP. Adenosine, lidocaine and Mg (ALM) (18):1854–1863.
resuscitation fluid protects against experimental traumatic brain 47. Dobson GP. Trauma of major surgery: a global problem that is
injury. J Trauma Acute Care Surg. 2018;84(6):908–916. not going away. Int J Surg. 2020. https://doi.org/10.1016/j.ijsu
33. Letson HL, Morris JL, Biros E, Dobson GP. ALM fluid therapy .2020.07.017
leads to 72 hr survival after hemorrhagic shock: a model for 48. Letson HL, Dobson GP. Correction of acute traumatic coagulop-
studying differential gene expression and extending biological athy with small-volume 7.5% NaCl adenosine, lidocaine, and
time. J Trauma Acute Care Surg. 2019;87(3):606–613. Mg2+ occurs within 5 minutes: a ROTEM analysis. J Trauma
34. Dominy JE, Puigserver P. Mitochondrial biogenesis through acti- Acute Care Surg. 2015;78(4):773–783.
vation of nuclear signaling proteins. Cold Spring Harb Perspect 49. Letson H, Dobson G. 7.5% NaCl resuscitation leads to abnor-
Biol. 2013;5(7):pii: a015008. mal clot fibrinolysis after severe hemorrhagic shock and its cor-
2+
35. Granfeldt A, Nielsen TK, Solling C, et al. Adenocaine and Mg rection with 7.5% NaCl, adenosine, lidocaine, and Mg . JETS.
2+
reduces fluid requirement to maintain hypotensive resuscitation 2018;11(1):15–24.
and improves cardiac and renal function in a porcine model of se-
vere hemorrhagic shock. Crit Care Med. 2012;40(11):3013–2540.

134 | JSOM Volume 20, Edition 3 / Fall 2020