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TABLE 2  Power Analysis Variables and Resulting Sample Sizes   many C-A-T7 occlusion and completion pressures were actu-
              Needed                                             ally higher than measured. Some strengths were placements on
                 Standard                                        human thighs; combination of controlled force applications
                 Deviation                Estimated              (Phase 1 thighs and models and Phase 2 models) and human
                (mmHg) for              Power Desired            applier variability (Phase 2 and 3); investigation of possible
                a Tourniquet   Minimum    to Rule In
                Applier for   Detectable    or Out a             effects on secured, occlusion, and completion pressures; and
              Secured Pressure   Pressure   Statistically        use of several different tourniquet designs.
                 and for a   Difference   Significant   Estimated
               Recipient Thigh   Created by    Difference with   Number
               for Occlusion   Clothing State   Two-Tailed    of Subjects   Conclusions
                 Pressure*    (mmHg)       p = .05   Required
                                Secured Pressure                 To avoid missing proximal injuries, guidelines for  emergency-use
                                                                 limb tourniquet applications in conditions other than Care Un-
                  32.8          10          0.80       193       der Fire  should still recommend placement on bare skin rather
                                                                      3
                                            0.65       145       than over clothing. However, applications over clothing with
                                            0.50       121       fabric pliability and coefficients of friction similar to scrubs
                                15          0.80        69       and Army uniform pants are unlikely to result in or need pres-
                                            0.65        52       sures that are significantly different from applications on skin.
                                            0.50        40       Surface to tourniquet interactions affect the ease of strap slid-
                                20          0.80        37       ing, so concern should still exist as to whether applications
                                            0.65        28       over clothing are dislodged in a distal direction more easily
                                            0.50        21       than applications on skin.
                                25          0.80        24       Acknowledgments
                                            0.65        18       We thank the undergraduates of the Drake University Trauma
                                            0.50        14       Research Team for all their help carrying out the experiments.
                               Occlusion Pressure
                  28.1          10          0.80       170       Disclosures
                                            0.65       137       None of the authors have any financial relationships relevant
                                            0.50       104       to this article to disclose, and there was no outside funding.
                                15          0.80        59
                                            0.65        45       Author Contributions
                                                                 PW and CB developed the concept and contributed to all as-
                                            0.50        34       pects of  the project. EH  and HS contributed to design;  the
                                20          0.80        32       acquisition, analysis, and interpretation of data; and the draft-
                                            0.65        24       ing and revising of the article. CHR contributed to design,
                                            0.50        18       the analysis and interpretation of data, and the drafting and
                                25          0.80        21       revising of the article. All authors had final approval of the
                                            0.65        16       manuscript.
                                            0.50        12
              *Secured pressure standard deviations are an average for the C-A-T7,   References
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