Page 176 - Journal of Special Operations Medicine - Spring 2017
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          mosquito repellent. Regardless of the repellent chosen,   Here’s the WHO list of superbugs:
          it is vital for patients to follow all instructions/precau-
          tions in the product labeling to ensure safe and effective   Priority 1: CRITICAL
          use.” 2016;36(12):1272–1280.                       1. Carbapenem-resistant Acinetobacter baumannii
                                                             2. Carbapenem-resistant Pseudomonas aeruginosa
                                                             3.  Carbapenem-resistant, ESBL-producing
                               n   n   n                        Enterobacteriaceae

          WHO Superbug List:                                 Priority 2: HIGH
          Enemy No. 1 Is Bug That Plagues Soldiers           1.  Vancomycin-resistant Enterococcus faecium
                                                             2.   Methicillin-resistant, vancomycin-intermediate and
          As reported by Maggie Fox (http://www.nbcnews.com     resistant Staphylococcus aureus
          /health/health-news/who-s-superbug-list-enemy-no   3.  Clarithromycin-resistant Helicobacter pylori
          -1-bug-plagues-soldiers-n726311), “Drug-resistant germs    4.  Fluoroquinolone-resistant Campylobacter and
          that caused horrible wound infections among soldiers in   Salmonellae
          the Vietnam conflict and bloodstream infections among   5.  Cephalosporin- and fluoroquinolone-resistant
          military patients in Iraq and Afghanistan top a new list   Neisseria gonorrhoeae
          of superbug enemies put out by the World Health Or-
          ganization. It’s the first-ever priority list written up by   Priority 3: MEDIUM
          WHO, which wants to push drug companies and gov-   1.  Penicillin-resistant Streptococcus pneumoniae
          ernments to put money and effort into developing new   2.  Ampicillin-resistant Haemophilus influenzae
          and better antibiotics.                            3.  Fluoroquinolone-resistant Shigella

          “At the top of the list are carbapenem-resistant Acineto-
          bacter baumannii and two other bacteria that resist the                 n   n   n
          effects of carbapenem antibiotics—the big guns in the
          medical arsenal. They are not common among healthy   Bad Medicine, or sometimes the only thing worse
          people but are extremely resistant to drugs and lethal to   than being excluded from a clinical trial is being
          infected patients.                                 included
                                                             Freakonomics Radio,  an American public radio pro-
          “‘Certainly Acinetobacter are something that we have   gram that discusses socioeconomic issues for a general
          seen in our returning military service people,’ said Dr   audience, is hosted by journalist Stephen Dubner, with
          Helen Boucher of the Infectious Diseases Society of   economist Steven Levitt as a regular guest and presented
          America.”                                          as a weekly podcast.

          Dr Rupa Kanapathipillai of Doctors Without Borders   In a three-part series, Stephen J. Dubner  looks at the
          said drug-resistant infections are a big problem in devel-  mistakes produced by centuries of trial-and-error and
          oping countries and especially in areas of conflict.  asks whether the new era of evidence-based medicine is
                                                             the solution. The following is an excerpt from the sec-
          “We see—with alarming regularity—the critical-listed   ond podcast.
          bacterial infections in people we treat in the field, in-
          cluding babies and children, burn victims and conflict   VINAY PRASAD [oncologist and an assistant professor
          and trauma injuries,” said Kanapathipillai. “It’s getting   of medicine at Oregon Health and Science University]:
          harder to treat people for drug-resistant infections in the   So much of the research agenda, even the randomized-
          resource-limited settings in which we work. With the   trial research agenda, is driven by the biopharmaceutical
          priority pathogen list, we need to urgently see new an-  industry. And that’s not necessarily a bad thing. I think
          tibiotics developed that are affordable, appropriate and   there’s many good things about that, that really drives
          accessible to fill a depleted drug pipeline.”      many, many trials; it drives a lot of good products. It



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