Page 352 - ATP-P 11th Ed

Warnings:
• Rapid administration may result in hypotension.
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• Do not co-administer with blood products or Hextend .
• Do not administer more than 3 hours after injury.
TMEP use:
• K9 Trauma Management Protocol
• Tactical Field Care and Tactical Evacuation Care Protocols
Trimethoprim-Sulfamethoxazole (TMP-SMZ, Bactrim , Septra )
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Aviation personnel are grounded for the initial 24hr of antibiotic therapy and until
the medical condition no longer interferes with safely performing aviation duties and the
patient is free of side-effects.
Description: Antimicrobial – antibacterial, sulfonamide
Action: Fixed combination of TMP and SMZ, synthetic folate antagonists and enzyme inhib-
itors that prevent bacterial synthesis of essential nucleic acids and proteins; effective against
SECTION 3 Pneumocystis carinii pneumonitis, Shigellosis enteritis, most strains of Enterobacteriaceae,
Nocardia, Legionella micdadei, and Legionella pneumophila, and Haemophilus ducreyi
Indications:
• Cellulitis
• Enteritis
• Urinary tract infections
Adult dose: 160mg TMP/800mg SMZ (DS) PO bid
K9 Dose: 15–30mg/kg PO q12–24hr (Skin Infection/UTI)
Contraindications:
• TMP, SMZ, sulfonamide, or bisulfite hypersensitivity
• Group A beta-hemolytic streptococcal pharyngitis
• Use caution with severe allergy or bronchial asthma.
• G6PD deficiency
• Pregnancy
Pregnancy Category C
Adverse effects:
• Rash
• Toxic epidermal necrolysis
• Nausea and vomiting
• Diarrhea
• Pseudomembranous enterocolitis
• Abdominal pain

342 SECTION 3 RECOMMENDED DRUG LIST (RDL)