Page 69 - 2021 Advanced Ranger First Responder Handbook

ARFR Pharmacology

ACETAMINOPHEN (TYLENOL) – Combat Wound Pillpack
Class: CNS agent – nonnarcotic, analgesic, antipyretic
Action: Pain medicine action possibly through peripheral nervous system; fever reduction through direct action on
hypo thalamus heat-regulating center resulting in peripheral vasodilation, sweating, and dissipation of heat; has mini-
mal effect on platelet aggregation, bleeding time, and gastric bleeding.
Dose: 325–975mg PO q6hr (max: 4g/day)
Onset/Peak/Duration: Onset varies/peak 1–3 hours/duration 3–4 hours.
Indications: For mild to moderate pain management, headache, fever reduction.
Contraindications: Acetaminophen hypersensitivity; use with alcohol.
Adverse/Side Effects: Negligible with recommended dose; rash; acute poisoning: anorexia, nausea, vomiting, diz-
ziness, lethargy, diaphoresis, chills, epigastric or abdominal pain, diarrhea; hepatotoxicity: elevation of liver function
tests; hypoglycemia, hepatic coma, acute renal failure.
Interactions: Alcohol use may increase potential for hepatotoxicity.

MELOXICAM (MOBIC)
Class: NSAID; COX2 Inhibitor, anti-inflammatory, analgesic, antipyretic
Action: Inhibits cyclooxygenase
Dose: 7.5–15mg PO daily
Indications: For mild to moderate pain management.
Contraindications: NSAID or aspirin hypersensitivity; rhinitis, urticaria, angioedema, asthma; severe renal or hepatic
disease.
Adverse/Side Effects: Edema, flu-like syndrome, pain, abdominal pain, diarrhea, dyspepsia, flatulence, nausea, con-
stipation, ulceration, GI bleed, anemia, arthralgia, dizziness, headache, insomnia, pharyngitis, upper respiratory tract
infection, cough, rash, pruritus, urinary frequency, urinary tract infection (UTI).

2021 ADVANCED RANGER FIRST RESPONDER HANDBOOK 59 MISC