Page 175 - 2026 SMOG

THIAMINE (VITAMIN B1)
Class/Mechanism of Action
• Vitamin, Water Soluble
Essential coenzyme in carbohydrate metabolism.
˚ Onset of action—IV/IM: Rapid
Indications
• Labeled Indications
˚ Treatment of thiamine deficiency, including beriberi, Wernicke’s encephalopathy,
Korsakoff’s syndrome, neuritis associated with pregnancy, or in alcoholic patients
Contraindications
• Hypersensitivity to thiamine or any component of the formulation
Adverse Reactions/Precautions
• Administration of dextrose may worsen acute symptoms of thiamine deficiency; use caution
when low thiamine is suspected.
• Flushing sensation, diaphoresis, pruritus, skin sclerosis, or tenderness at the IM injection site
• Cyanosis, pharyngeal edema, pulmonary edema
• Nausea
• Pregnancy: Category A
• Lactation: Use caution
Dose/Administration
PEDIATRIC
ADULT
(Always reference Broselow Tape)
AMS, Seizure, Syncope, Malnutrition, Nutrition Maintenance Requirement
Vomiting and Diarrhea, with Hx of • IV/IM
EtOH Abuse ˚ Infants: 0.35–0.5mg/kg/day
• IV/IM (max DAILY dose: 1.2mg/day)
˚ 100mg/day ˚ Children: 1.2mg/day

2026 Standard Medical Operating Guidelines (SMOG) • 167