Page 126 - 2026 SMOG

ETOMIDATE (AMIDATE)
Class/Mechanism of Action
• General Anesthetic
Ultrashortacting nonbarbiturate sedative/hypnotic used for induction of anesthesia
˚ Onset of action: 30–60sec; Duration: 5–10min
Indications
• Labeled Indications
˚ Rapid Sequence Induction
Contraindications
• Hypersensitivity to etomidate or any component of the formulation
• Labor/Delivery
Adverse Reactions/Precautions
• No analgesic properties!
• Apnea/Respiratory Depression
• Hypo/hyperventilation
• Dysrhythmia
• Hypo/hypertension
• Nausea/Vomiting
• Transient involuntary skeletal muscle movement
• Pain at injection site
• Inhibits adrenal steroid production; may increase mortality if repeat dosing is required
• Pregnancy: Category C
• Lactation: Use caution
Dose/Administration
PEDIATRIC
ADULT
(Always reference Broselow Tape)
Rapid Sequence Induction Rapid Sequence Induction
• IV/IO • IV/IO
˚ 0.3mg/kg over 30–60sec for induction of ˚ 0.3mg/kg over 30–60sec will produce
rapid sedation lasting 10–15min (max
anesthesia
Note: Limit to a single dose for anesthesia/ dose: 20mg)
induction Note: Limit to a single dose foranesthesia/
induction

118 • MEDICATIONS