Page 125 - 2026 SMOG

ERTAPENEM (INVANZ)
Class/Mechanism of Action
• Antibiotic (Carbapenem)
Bactericidal—broad-spectrum. Inhibits bacterial cell wall synthesis by binding to one or more
of the penicillinbinding proteins, which inhibit cell wall biosynthesis, causing bacteria to lyse
eventually.
Indications
• Labeled Indications
˚ Used for infection control prophylaxis for traumatic open injuries and surgical prophylaxis
Contraindications
• Hypersensitivity to any component of this product or to other drugs in the same class, or in
patients who have demonstrated anaphylactic reactions to other betalactams (e.g., penicillin and
cephalosporins)
Adverse Reactions/Precautions
• Superinfection: prolonged use may result in fungal or bacterial superinfection (including
C. Difficile)
• Gastrointestinal: Diarrhea (Adults 9–12%)
• CNS Stimulation/Toxicity: AMS, aggressive behavior, anxiety, tremors, seizures,
encephalopathy
• Pregnancy: Category C
• Lactation: Yes
Dose/Administration
PEDIATRIC
ADULT
(Always reference Broselow Tape)
Infection Control Infection Control
• IV/IO • IV/IM
˚ 1g in 250mL NS over 5min q24hr ˚ Infants and Children: 15mg/kg/dose
q12hr
(provides 24hr of coverage). Repeat for
7–10 days prn ■ Maximum dose: 500mg
Infection Prophylaxis ˚ Adolescents: 1000mg once daily
• IV/IO
˚ 1g in 250mL NS over 5min q24hr
(provides 24hr of coverage)

2026 Standard Medical Operating Guidelines (SMOG) • 117