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the presentation, diagnosis, and treatment of the cases but lack   Optimization of Surgical and Triage Protocols
          discussion of complications or risks. More details are pre-  Based on metric analyses of injury patterns, it was possible to
          sented as supplemental material in Table S1.       differentiate and refine surgical, triage, and evacuation princi-
                                                             ples at various levels of medical care. A standardized classifi-
          The STROBE assessment of the reviewed studies indicates that   cation system was proposed, correlating wound dimensions,
          all studies clearly described their titles, abstracts, rationales,   volume, and anatomical localization with the appropriate
          objectives, study designs, participant criteria, data sources,   medical response and surgical strategy.  Upon arrival at medi-
                                                                                           41
          statistical methods, and ethical considerations. Most studies   cal facilities, patient categorization into surgical and therapeu-
          provided detailed outcome data, key results, and appropriate   tic cycles was crucial for optimizing resource allocation and
          tables/figures, ensuring a comprehensive presentation of find-  treatment efficiency. The presence of gunshot fractures often
          ings. However, several limitations were observed, including a   necessitated specialized referrals, with some cases requiring
          lack of discussion of potential biases, the absence of sample   transfer to civilian hospitals during mass casualty incidents.
          size justification, and the failure to acknowledge study limita-
          tions in many studies. More details are presented as supple-  Most patients underwent primary debridement, followed by
          mental material in Table S2.                       staged surgical interventions, including external fixation and
                                                             conversion to internal fixation; soft-tissue reconstruction
                                                             through flap techniques and VAC therapy; and amputee re-
          Discussion
                                                             habilitation with progressive prosthetic fitting, weight-bearing
          This systematic review analyzed 31 studies published between   training, and reintegration programs. 19,23,24,38
          2014 and 2024, comprising 19 structured observational studies
          and 12 individual case reports, all focused on military-related   Comparative Insights with Previous Military Conflicts
          injuries sustained during the ongoing Russian-Ukrainian con-  The treatment methodologies observed in the Ukrainian
          flict. The majority of these studies were case reports and retro-  conflict  share  notable  similarities  with  those  from  Iraq  and
          spective analyses, primarily based in Ukrainian military medical   Afghanistan,  where  staged  surgical  interventions  and  limb
          facilities and frontline hospitals, with a few involving Ukrainian   salvage techniques were widely practiced. However, advance-
          patients treated abroad. The study population predominantly   ments in wound management (including the expanded use of
          comprised male military personnel aged 24 to 40, although ci-  VAC therapy and 3D-printed implants for arthrodesis) reflect
          vilian casualties have significantly increased in recent years.  a progressive shift in combat casualty care. 25,29  Unlike previous
                                                             conflicts, where high amputation rates were largely due to lim-
          The injuries observed were severe and complex, commonly   ited reconstructive capabilities, contemporary techniques such
          involving soft-tissue damage, fractures, amputations, and neu-  as distraction osteogenesis and bone transport have signifi-
          rological  trauma,  primarily  caused  by  high-energy  combat   cantly improved functional recovery and limb preservation.
          mechanisms, such as explosions, gunshots, and blast-related
          trauma. Surgical management played a critical role in acute   The Role of Telemedicine in Modern Combat Medicine
          treatment, including amputations, fracture fixation, nerve re-  Telemedicine represents a transformative innovation in ad-
          pair, and soft-tissue reconstruction, with advanced reconstruc-  dressing challenges faced by patients, medical administrators,
          tive techniques such as 3D-printed implants increasingly being   and frontline healthcare providers. Previous research suggests
          used. Rehabilitation strategies, including pain  management,   that 74% of patients prefer virtual consultations over in- person
          physiotherapy, and prosthetic  adaptation, were essential for   visits due to time and financial constraints.  Telemedicine
                                                                                                 42
          recovery, with select cases exploring regenerative medicine ap-  significantly reduces unnecessary hospital visits, facilitating
          proaches. While many patients successfully regained mobility   real-time consultations and expert guidance, particularly for
          and reintegrated into daily life, long-term complications such   patients in remote or combat zones. 43
          as chronic pain and PTSD necessitated prolonged follow-up
          and continued care.                                In the context of the Ukrainian Armed Forces, telemedicine
                                                             offers a viable alternative for multidisciplinary care, ensur-
          The Need for Multidisciplinary Rehabilitation Programs  ing timely consultations  across  different  levels  of medical
          Given the growing number of disabled individuals resulting   assistance. International partnerships with leading global med-
          from prolonged warfare, Ukraine urgently requires the imple-  ical institutions further enhance the quality of telemedicine-
          mentation of multidisciplinary rehabilitation programs guided   enabled specialist consultations, enabling real-time collabora-
          by unified principles and coordinated strategies. Research in-  tion on complex medical cases. 41,44,45
          dicates that a comprehensive approach to the rehabilitation
          of disabled war veterans should integrate medical, social, and   A notable example is the collaboration between the Charité
          psychological components, ensuring an individualized and ho-  Clinic in Berlin and the Military Medical Clinical Center
          listic treatment framework. 39,40                  (MMCC)  of Ukraine’s Southern  Region, facilitated  by  the
                                                             Teladoc  Health  system.  This  initiative  enabled  multimodal
          During the armed conflict, surgeons frequently encounter   screening and preoperative planning, comprehensive indicator
          severe soft-tissue defects caused by gunshot wounds, exacer-  analysis and patient monitoring, and the integration of multi-
          bated by the unpredictable and high-intensity nature of hos-  disciplinary teams, including specialists in plastic surgery, trau-
          tilities. Addressing such injuries demands a multidisciplinary   matology, anesthesiology, and resuscitation.
          approach, involving vascular, orthopedic, general, and tho-
          racic surgeons. As a result, the deployment of specialized med-  Such international telemedicine collaborations not only ele-
          ical personnel and the optimization of triage and evacuation   vate the standard of medical care but also streamline complex
          strategies become critical considerations in improving early   surgical planning and postoperative monitoring, ensuring con-
          medical intervention. 41                           tinuity of care in conflict-affected regions. 30

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