Page 155 - PJ MED OPS Handbook 8th Ed

Aspirin (ASA)
• Description: analgesic, antipyretic, anti-inflammatory, anti-platelet effect
• Indications: myocardial infarction treatment; transient ischemic attacks, blood clot, prevention
of blood clots for patients immobilized for greater than 24 hours (per medical control only)
• Adult dose: 325mg × 2q3–4hr
Contraindications: hypersensitivity to aspirin or other NSAIDs, history of gastrointestinal bleed-
ing, patients with bleeding disorders (e.g., hemophilia), patient age <16 years old, pregnancy
• Side-effects: gastrointestinal symptoms including pain and bleeding
• Adverse reactions: interacts with NSAIDs, coumadin, heparin

Atovaquone 250mg/Proguanil 100mg (Malarone )
®
GROUNDING medication for personnel on flight status
• Description: Antimalarial
• Indications: prophylaxis and treatment of Plasmodium falciparum malaria
• Adult Dose:
There are pediatric tablets as well as adult tablets
○ Prophylaxis:
n Start treatment 1 or 2 days prior to entering malaria endemic area and continue daily
during the stay and for 7 days after return
n 1 tablet (adult strength) daily
○ Treatment:
n 4 tablets (adult strength; total daily dose atovaquone 1g/400mg proguanil) as a single
daily dose for 3 consecutive days
• Pediatric Dose:
There are pediatric tablets as well as adult tablets
○ Tablets may be crushed and mixed with condensed milk just prior to administration for
those having difficulty in swallowing tablets
○ Prophylaxis dosing based on body weight:
n Safety and efficacy for prophylaxis have been established for children >11kg
○ Treatment dosing based on body weight:
n Safety and efficacy for treatment have been established for children >5kg

Dosage of atovaquone/proguanil in prevention of malaria in pediatric patients
Weight (kg) Total daily dose Dosage regimen
11 to 20 62.5mg/25mg 1 pediatric tablet daily
21 to 30 125mg/50mg 2 pediatric tablets as a single daily dose
31 to 40 187.5mg/75mg 3 pediatric tablets as a single daily dose
>40 250mg/100mg 1 tablet (adult strength) as a single daily dose

Chapter 9. Pararescue Drug Formulary n 153