Page 68 - 2022 Spring JSOM

FIGURE 2 Depiction of study timeline. Recorded values pre- and post-transport for vital sign data
are shown in Table 1 and for blood gas data in Table 2; it is
important to note that values for preTransport1 and preTrans-
port3 were collected while the animal was on the V500 ICU
ventilator, serving as “gold standard” measurements as stan-
dard of care therapy. The PIP limit was the only variable to
show a difference pre- and post-transport (pre- vs post-trans-
port for transport 1, 21 ± 1 vs. 28 ± 2 cm H O; transport 2, 29
2
± 2 vs. 22 ± 1 cm H O; transport 3, 40 ± 3 vs. 46 ± 4 cm H O;
2
2
transport 4, 48 ± 5 vs. 36 ± 5 cm H O). Additionally, increases
Transports were conducted in uninjured state on day 1 and in injured 2
state on day 2 (n = 11 animals; 33 transports total). Data were collected were seen in mean arterial blood pressure after transport 1
before and after each transport, before departure from the origin ICU (leaving the origin ICU) and in minute volume, end-tidal CO ,
2
(while on the V500) and upon arrival in the experimental ICU (while and in PFR after transport 2 (return to the origin ICU) (Tables
on the SAVe II), and then again before departure from the experimental 1 and 2).
ICU (on the SAVe II) and upon return to the origin ICU (on the V500).
TABLE 1 Collected Vital Signs Data From Pre- and Post-Ground Transports*
Day 1 Day 2
Pre Post Pre Post Pre Post Pre Post
Transport 1 Transport 1 Transport 2 Transport 2 Transport 1 Transport 1 Transport 2 Transport 2
Vital Sign V500 SAVe II SAVe II V500 V500 SAVe II SAVe II V500
Heart rate 115 ± 9 97 ± 11 93 ± 10 105 ± 7 128 ± 12 101 ± 16 94 ± 13 99 ± 12
ABP/M 80 ± 3 87 ± 4*** 87 ± 4 83 ± 2 54 ± 3 79 ± 10 89 ± 7 91 ± 10
V T 381 ± 19 415 ± 26 369 ± 29 391 ± 24 296 ± 33 322 ± 42 322 ± 42 308 ± 50
V /kg 7.3 ± 0.3 7.7 ± 0.4 6.9 ± 0.6 7.5 ± 0.5 5.4 ± 0.6 5.3 ± 0.6 5.3 ± 0.6 5.5 ± 1.2
T
RR 9 ± 1 10 ± 1 9 ± 1 12 ± 1 16 ± 3 12 ± 1 12 ± 1 11 ± 2
V 3.71 ± 0.37 4.10 ± 0.47 3.48 ± 0.54 5.00 ± 0.79 3.69 ± 0.66 3.84 ± 0.74 3.84 ± 0.74 3.59 ± 0.91
E
PIP** 21 ± 1 28 ± 2*** 29 ± 2 22 ± 1 40 ± 3 46 ± 4*** 48 ± 5 36 ± 5***
PEEP 6 ± 1 6 ± 1 6 ± 1 6 ± 1 6 ± 1 8 ± 1 8 ± 1 8 ± 1
etCO 32 ± 2 31 ± 2 28 ± 2 31 ± 3*** 18 ± 3 29 ± 5 25 ± 5 26 ± 3
2
Blood flow 1.12 ± 0.10 1.31 ± 0.16 1.34 ± 0.15 1.30 ± 0.15 1.53 ± 0.23 2.03 ± 0.30 2.01 ± 0.29 2.00 ± 0.29
RPM 2103 ± 181 2327 ± 211 2364 ± 212 2185 ± 186 3171 ± 200 3254 ± 419 3274 ± 398 3256 ± 413
Sweep gas flow 4.9 ± 1.2 5.9 ± 1.3*** 2.0 ± 0.3 1.4 ± 0.7 7.7 ± 1.3 9.0 ± 1.9 9.4 ± 1.7 8.4 ± 1.0
Spo % 94 ± 1 95 ± 3 97 ± 1 95 ± 1 89 ± 5 95 ± 2 98 ± 1 98 ± 1
2
Fio % 23 ± 1 49 ± 13 43 ± 8 32 ± 8 85 ± 8 78 ± 14 82 ± 11 90 ± 10
2
PFR 342 ± 18 388 ± 22 433 ± 30 380 ± 25*** 231 ± 47 181 ± 44 252 ± 63 218 ± 43
SFR 424 ± 22 283 ± 67 309 ± 48 361 ± 39 135 ± 19 142 ± 29 131 ± 21 122 ± 24
*n = 11 animals; 33 transports total. Data are represented as mean ± SEM.
**For SAVe II, PIP values reported are PIP limits because the SAVe II model we tested does not display measured PIP.
***Denotes significant difference between pre- and post-transport data, p < .05.
Heart rate, beats per minute (bpm); ABP/M, mean arterial blood pressure (mmHg); V , tidal volume (mL); V /kg, tidal volume per kilogram of
T
T
bodyweight (mL); RR, respiratory rate (bpm); MV, minute ventilation (L); PIP, peak inspiratory pressure (cm H O); PEEP, positive end-expiratory
2
pressure (cm H O); etCO , end-tidal carbon dioxide (mmHg); blood flow: extracorporeal life support (ECLS) blood flow (L/minute); RPM, ECLS
2
2
pump revolutions per minute; sweep gas flow, sweep gas flow rate (L/minute); Spo %, pulse oximetry saturation percentage; Fio %: fraction of
2
2
inspired oxygen percentage; PFR, ratio of Pao to Fio ; SFR, ratio of Spo to Fio .
2 2 2 2
TABLE 2 Collected Arterial Blood Gas Data From Pre- and Post-Ground Transport*
Day 1 Day 2
Pre Post Pre Post Pre Post Pre Post
Blood Gas Transport 1 Transport 1 Transport 2 Transport 2 Transport 1 Transport 1 Transport 2 Transport 2
Factor V500 SAVe II SAVe II V500 V500 SAVe II SAVe II V500
pH 7.55 ± 0.03 7.55 ± 0.04 7.55 ± 0.04 7.47 ± 0.04** 7.45 ± 0.02 7.36 ± 0.04** 7.37 ± 0.02 7.28 ± 0.08
Paco 30.0 ± 2.1 30.8 ± 3.3 26.8 ± 1.4 32.9 ± 2.7** 27.2 ± 2.5 34.1 ± 3.6 29.2 ± 2.8 39.3 ± 8.4
2
Pao 2 76.4 ± 3.5 204.0 ± 59.5** 179.6 ± 34.4 128.2 ± 33.0 192.3 ± 47.1 117.8 ± 11.6 185.8 ± 33.3 201.0 ± 50.6
BE 3.1 ± 0.8 3.9 ± 1.3 0.8 ± 1.8 –0.4 ± 1.3 –5.4 ± 1.7 –6.6 ± 2.0 –8.6 ± 2.3 –9.0 ± 2.3
HCO – 25.6 ± 0.6 26.7 ± 1.0 24.1 ± 1.4 23.5 ± 0.9 18.6 ± 1.6 19.2 ± 1.7 17.3 ± 2.0 18.2 ± 1.6
3
Sao % 96.8 ± 0.6 98.9 ± 0.5 99.5 ± 0.21** 98.0 ± 0.5** 96.6 ± 2.1 98.0 ± 0.8 99.4 ± 0.4 98.2 ± 1.2
2
Lactate 2.53 ± 0.59 3.57 ± 1.11 4.23 ± 1.29** 3.16 ± 0.96** 4.56 ± 0.94 4.55 ± 1.93 5.93 ± 1.94 10.22 ± 4.22
*n = 11 animals; 33 transports total. Data are represented as mean ± SEM.
**Denotes significant difference between pre- and post-transport data, p < .05.
pH, log scale of hydrogen ion concentration in blood; Paco , arterial partial pressure of carbon dioxide (mmHg); Pao , arterial partial pressure
2
2
–
of oxygen (mmHg); BE, base excess (mmol/L); HCO , bicarbonate (mmol/L); Sao %, arterial oxyhemoglobin saturation (%); lactate, arterial
2
3
lactate (mmol/L).
66 | JSOM Volume 22, Edition 1 / Sping 2022