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5.  Current evidence suggests initial calcium supplementation is   and a Navy undersea medical officer with more than 20 years of ex-
            warranted in major trauma, especially for patients who may   perience providing medical support to Special Operations Forces. Dr
            require massive transfusion. At this point, there is conflict-  Butler has served as the command surgeon at the US Special Oper-
                                                             ations Command and was the chairman of the Department of De-
            ing evidence on the type of calcium salt administered, spe-  fense’s Committee on TCCC for 11 years. He currently serves as a
            cific initial dose and pursuant re-dosing recommendations.  consultant to both the JTS and the CoTCCC.  SO1 Terence Byrne,
                                                                                              5
          6.  Many whole blood donor protocols exclude females as po-  USN, is a Special Operations SEAL Medic and Special Operations
            tential candidates because of concern that blood from fe-  Combat Medic (SOCM). He previously served as the medical leading
            male donors may entail a higher risk of transfusion-related   petty officer for SOTM, Naval Special Warfare, Advanced Training
                                                             Command and is now a first-year medical student at Tulane Univer-
            acute lung injury (TRALI). Given the significant number of   sity.  COL Andrew Cap MD, PhD, MC, USA, is the division chief,
                                                                6
            female service members who serve in deployed and combat   Acute Combat Casualty Care Research, US Army Institute of Surgical
            positions, further investigation into the donor and recipi-  Research. He first trained and worked as an EMT and then as an
            ent safety profiles for female whole blood transfusions are   internist, hematologist, oncologist, and specialist in stem cell trans-
                                                             plantation, coagulation disorders, and transfusion medicine. He is the
            required.                                        hematology and oncology consultant to the Army Surgeon General
          7.  For the trauma patient in extremis, initiation of fluid resus-  and has consulted extensively for the Joint Trauma System and Spe-
            citation is dependent upon obtaining rapid vascular access.   cial Operations Command. He serves as co-chair of the NATO Blood
                                                                  7
            Emergent intraosseous (IO) access is twice as likely to be   Panel.  LTC Benjamin Donham, MD, USA, is the commander of the
            successful as peripheral intravenous attempts. Optimal IO   261st Multifunctional Medical Battalion and has multiple deploy-
                                                             ments with austere surgical teams in support of overseas contingency
            blood infusion strategies that will provide sufficient volume   operations.  Colonel Joseph J. DuBose, MD, USAF, serves as director,
                                                                     8
            to meet resuscitation demands but that avoid the potential   Center for the Sustainment of Trauma and Readiness Skills (CSTARS)
            complications, such as hemolysis in the infused blood, that   at R Adams Cowley Shock Trauma Center/University of Maryland in
            may result from overpressurized IO infusion techniques.   Baltimore, Maryland. Col DuBose is a professor of surgery at USUHS
                                                             and the University of Maryland and is board certified in general sur-
            Further research is needed to help develop improved rec-  gery, vascular surgery, and surgical critical care. He has over 230
            ommendations for prehospital IO infusion strategies.  published peer review publications as an active-duty military surgeon
                                                             with the United States Air Force and has deployed seven times as a
                                                             trauma surgeon to combat theaters in both conventional and JSOC
          Acknowledgments                                    roles.  MAJ Andrew D. Fisher, MD, PA-C, ARNG, is a physician as-
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          The  authors  gratefully  acknowledge  the  research  assistance   sistant in the Texas Army National Guard, a recent graduate from the
          provided by Mrs Danielle Davis of the Joint Trauma System.   Texas A&M University College of Medicine, and a general surgery
          The authors also thank the Department of Defense Trauma   resident at the University of New Mexico School of Medicine. He pre-
          Registry for providing much of the casualty data discussed in   viously served on active duty as a physician assistant within USASOC.
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          this paper.                                         RDML James Hancock, MD, USN, is an emergency physician with
                                                             multiple combat deployments. He has served as a flight surgeon, as
                                                             OIC of a fleet surgical team and as OIC of a shock trauma platoon.
          Disclaimers                                        He is currently serving as the Medical Officer of the Marine Corps/
          The opinions or assertions contained herein are the private   director, Health Services, Headquarters Marine Corps with additional
                                                                                                   11
          views of the authors and are not to be construed as official or   duty as the Chief of the Medical Corps for the Navy.  LCDR Victor
          as reflecting the views of the Defense Health Agency or the De-  Jourdain, MD, USN, is an emergency medicine physician and senior
                                                             medical officer at the Naval Medical Center San Diego Emergency
          partment of Defense. This recommendation is intended to be   Department. As a Fleet Marine Force qualified officer, he completed
          a guideline only and is not a substitute for clinical judgment.  multiple combat deployments in support of Role 1 and Role 2 eche-
                                                                      12
                                                             lons of care.  LTC Ryan Knight, MD, USA, was an infantry platoon
                                                             leader, leading platoons in Afghanistan and Iraq, prior to becoming
          Disclosures                                        a physician. As an emergency physician he served seven years at Ft.
          The authors have no disclosures to report.         Bragg, NC deploying numerous times to Afghanistan and austere lo-
                                                             cations in Africa with a Joint Task Force. He has extensive experience
          Release                                            training medics, APPs, and physicians in austere/operational medicine.
                                                                                                       th
          This  document  was reviewed  by  the  Director  of the  Joint   Ryan is currently serving as the regimental surgeon for the 75  Ranger
          Trauma System and by the Public Affairs Office and the Oper-  Regiment and is the primary author of the 2019 and 2020 Ranger
                                                             Medic Handbooks.  CAPT Lanny Littlejohn, MD, USN, is a prior US
                                                                           13
          ational Security Office at the DoD’s Defense Heath Agency. It   Marine who now serves as an emergency physician for the US Navy.
          is approved for unlimited public release.          He has served as a flight surgeon, diving medical officer, shock trauma
                                                             platoon leader, and command surgeon for multiple US Marine Corps
                                                             and US Special Operations command units. He is currently the force
                                                             surgeon for Naval Special Warfare Command.  Colonel Matthew J.
                                                                                              14
                                                             Martin, MD, US Army (retired), is a trauma and acute care surgeon
          1 CAPT Travis Deaton, MD, USN, is the 1st Marine Division surgeon   at Scripps Mercy Hospital and the Navy Medical Center San Diego.
          and most recent chair of Emergency Medicine at Naval Medical Center   He recently retired from active military service as the trauma director
          San Diego. As a prior flight surgeon and dive medical officer, he has 13   and director of surgical research at Madigan Army Medical Center,
                                               2
          deployments in support of USMC and SOCOM units.  CDR Jonathan   where he established and directed a highly productive basic science
          Auten, DO, USN, is the program director of the Emergency Medicine   and translational trauma research lab. He served in a variety of clin-
          Residency at Naval Medical Center San Diego. He has served as a car-  ical and leadership positions during five deployments in support of
                                                                                             15
          rier airwing flight surgeon, US Marine Corps shock trauma platoon   combat operations in Iraq and Afghanistan.  HMC Kevin Toland,
          leader, and detachment OIC for SOUTHCOM humanitarian efforts.   USN, is a Special Operations independent duty corpsman (SOIDC)
          He has a wide area of research involvement in prehospital and austere   and advanced tactical paramedic (ATP). He is currently serving as a
          medicine with specific interests in pediatric trauma, hemostatic resus-  Special Operations combat medic (SOCM) course instructor and is
          citation and intraosseous blood transfusion.  Maj Richard Betzold,   the NCOIC of the Prolonged Casualty Care (PCC) section. He has
                                          3
          MD, USAF, is a trauma surgeon who has multiple deployments with   deployed multiple times in both conventional and SOF roles.  CAPT
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          the Joint Special Operations Command. He currently works at the     Brendon Drew, DO, USN, is the Chair of the Joint Trauma System
          R Adams Cowley Shock Trauma Center and is an instructor in the   Committee on Tactical Combat Casualty Care. He currently serves
          Air Force Center for Sustainment of Trauma and Readiness Skills pro-  as the I Marine Expeditionary Force Surgeon. He has 8 deployments
               4
          gram.  CAPT (Ret) Frank Butler, USN, was a Navy SEAL platoon   across Asia, Afghanistan, Iraq, Africa and 11 ships in support of both
          commander before becoming a physician. He is an ophthalmologist   USMC and SOCOM units.
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