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and Air Combat Command. Participating units included the US   TABLE 1  Injury Demographics
          Army’s 75th Ranger Regiment, 160th Special Operations Avi-  Injury Type and MOI  Number of Injuries  Percent of Injuries
          ation Regiment, and US Air Force Pararescue. The deidentified   Back       4             11.76%
          data was collected from After Action Reviews (AARs) in an   Airborne Ops   2              5.88%
          anonymous manner from training mishaps and injuries. The
          AARs were part of ongoing internal Quality Assurance/Quality   Other       1              2.94%
          Improvement measures. The skill level of the medical providers   Unknown   1              2.94%
          included special operations combat medic (SOCM) or para-  Extremity       23             67.65%
          rescueman (PJ), physician assistant, and physician. Descriptive   Airborne Ops  3         8.82%
          statistics were used to calculate the doses per administration to   Penetrating  1        2.94%
          include the interquartile range (IQR), standard deviation (SD)   Unknown  19             55.88%
          and the range of likely doses using a 95% confidence interval   Head/neck  1              2.94%
          (CI). A Wilcoxon signed-rank test was utilized to compare the   Blunt      1              2.94%
          mean pre-ketamine pain scores to the mean post-ketamine on   Pelvic        3              8.82%
          a 0-to-10 pain scale.                                Unknown               3              8.82%
                                                              Polytrauma             3              8.82%
          Results                                              Other                 1              2.94%
          From July 2010 to October 2017, there was a total of 34   Penetrating      1              2.94%
          patients in whom ketamine  was used for training injuries,   Unknown       1              2.94%
          all  were male.  Due  to reporting limitations,  ages  were  not   Total  34            100.00%
          reported in all cases; furthermore, there was some pain data
          lacking within the set, therefore this was not reported in the   was back injuries sustained by 4 (11.76%), followed by both
          final data. The data that was not available for four of the pa-  pelvic and polytrauma injuries each having 3 (8.82%) inci-
          tients was documentation regarding their level of pain pre and/  dents. There was only 1 (2.94%) head/neck injury sustained.
          or post administration of ketamine. The injury patterns for   The leading causing MOI were the “unknown” injuries with
          training injuries were also reviewed.              24 (70.59%) not being noted in the data. The second leading
                                                             MOI was airborne operations with 5 (14.71%) casualties, fol-
          The training injuries were delineated by the type of injury and   lowed by other and penetrating each with 2 (5.88%) incidents
          the mechanism of injury (MOI) based on the documentation   and one (2.94%) incident of blunt trauma. Ketamine was used
          provided by the units (Table 1). The injury types determined   to treat all of these casualties.
          in the study included: back, extremity, head/neck, pelvic, and
          polytrauma. In the cases for two documented injuries, the po-  The mean total dose of all ketamine administration was
          tentially most severe injury was used as the primary injury.   90.29mg (95% CI, 70.09–110.49) (Table 2). The mean num-
          “Back” injuries were musculoskeletal injuries to the back.   ber of ketamine doses via all routes administered to patients
          “Extremity” injuries were any injuries to the extremity such as   was 1.88 (SD 1.094) (Table 3). The mean initial dose of all ket-
          a fracture or gunshot wound. “Head/neck” injuries included   amine administration was 47.35mg (95% CI, 38.52–56.18).
          musculoskeletal and/or blunt trauma. “Pelvic” injuries were   Nineteen (55.9%) of the patients received a second dose of
          injuries sustained to pelvis. Last, “Polytrauma” was deter-  ketamine. The mean second dose was 62.89mg (SD 60.903;
          mined to be three or more documented injuries. The injuries   95% CI, 35.51–90.28). Seven (20.6%) received a third dose,
          were categorized into MOI.                         with a mean of 23.57mg (SD 12.488; 95% CI, 14.32–32.82),
                                                             while only 3 (8.8%) patients received a fourth dose of ket-
          There were five MOI determined for this study. The MOI in-  amine with a mean of 26.67mg (SD 20.817; 95% CI, 3.11–
          cluded: airborne operations (airborne ops), blunt, penetrating,   50.23). Only 1 (2.9%) casualty received a total of six doses of
          other, and unknown. “Airborne operations” included injuries   ketamine, at 10mg for both doses five and six.
          sustained during any operations involving exiting an aircraft
          while in flight. “Blunt” were simply determined to be an MOI   Of the 34 patients, a total of 22 (64.7%) received ketamine
          with no penetrating injuries such as a fall; thereby, “penetrat-  via intravenous (IV) route (Table 4). Intramuscular (IM) route
          ing” MOIs were those that penetrated the patient’s body in   of administration was used for a total of 12 (35.3%) patients.
          some manner. “Other” indicated MOI that did not fit into the   Initially, 10 (29.4%) of the patients received an IM dose and
          previously described categories, yet had an outlying MOI in   2 (5.9%) received additional doses via IM route. Intranasal
          the documentation by which this was the only MOI of that   (IN) doses of ketamine were used for 8 (23.5%) patients for
          type in the data, such as “Rappel accident.” Finally, “un-  the first dose. Last, none of the training patients were noted to
          known” was used to categories injuries where no MOI was   have received intraosseous (IO) doses of ketamine, though IO
          documented.                                        is a potential route of administration. 4

          The most common training injury type appears to be extrem-  There were 16 (47.1%) patients who received their first dose
          ity injuries with a total of 23 (67.65%) of the casualties sus-  of ketamine via IV, the mean dose was 48.44mg (SD 28.967;
          taining these injuries. The second most common injury type   95% CI, 34.25–62.63) (Table 5). There were 10 (29.4%)


          TABLE 2  Ketamine Dosing (mg) for All Training Casualties
           Number of Casualties  Mean Dose (SD)  95% CI     Range   Minimum Dose   Maximum Dose      IQR
                  34         90.29 (60.098)  70.09–110.49   310          15            325            83


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