Page 167 - 2026 SMOG

PROPOFOL (DIPRIVAN)
Class/Mechanism of Action
• General Anesthetic
Lipophilic intravenous general anesthetic.
˚ Onset of action—IV bolus: 9–51sec (average 30 sec); Duration—Dose and rate dependent:
3–10min, prolonged with continued doses
Indications
• Labeled Indications
˚ Induction of anesthesia in patients ≥3 years of age; maintenance of anesthesia in patients
>2 months of age; sedation in intubated, mechanically ventilated ICU patients
Contraindications
• Hypersensitivity to propofol or any component of the formulation
• Allergy to eggs, egg products, soybeans, soy products, and peanuts
Adverse Reactions/Precautions
• It may cause hypotension, especially in hypovolemic patients or if bolus dosing is used.
˚ Hypotension may result in a reduction of MAP exceeding 30%. Head Injury patients or those
with suspected or known increased intracranial pressure are at increased risk of decreased
cerebral perfusion pressure.
• Do not use in pre-hospital trauma environments or in burn transfer patients unless directed by
the medical director or provided written orders by the referring provider.
• No Analgesic properties. Must supplement with analgesic agents
• Potential to cause seizures
• Pediatrics: use with opioids may cause serious bradycardia
• Pregnancy: Category B
• Lactation: Not recommended
Dose/Administration
PEDIATRIC
ADULT
(Always reference Broselow Tape)
Sedation/RSI Sedation/RSI
• IV Push • IV Push
˚ 1–2.5mg/kg q5–10min prn ˚ 1–2.5mg/kg q5–10min
Maintenance of General Anesthesia Maintenance of General Anesthesia
• IV Infusion • IV Infusion
˚ 5–75mcg/kg/min via infusion pump ˚ 16–66mcg/kg/min (or 1–4mg/kg/hr)
or Dial-a-Drip. Titrate to the minimum
effective dose (max dose: 100mcg/kg/min).
See the infusion chart on the next page.
Note: Use of Dial-a-Drip tubing in the absence
of an infusion pump will increase the accuracy
of infusion dosage
Note: Wait 3–5min between dosage changes to
clinically assess drug effects. Smaller doses are
required when used with opioids.
Note: Not preferred in Burn patients in the first
48–72hr

2026 Standard Medical Operating Guidelines (SMOG) • 159